Journal: Antimicrobial Agents and Chemotherapy

Article Title: New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

doi: 10.1128/AAC.01814-20

Figure Lengend Snippet: Mechanism of remdesivir. (Step 1) Entry of SARS-CoV-2 into the target cell by binding to the ACE-2 receptor on the cell surface. (Step 2) Once SARS-CoV-2 enters the cell, it releases its viral RNA. (Step 3) SARS-CoV-2 uses the host machinery to translate RNA into RNA-dependent RNA polymerase (RdRp). (Step 4) RdRp is then used to facilitate viral replication. (Step 5) Once remdesivir enters the cell, it is converted into remdesivir triphosphate, which competes with endogenous ATP, which is used as a source of nucleotide, for incorporation into RdRp, leading to chain termination. (Courtesy of Lama Albadi, reproduced with permission.)

Article Snippet: Remdesivir is a potentially broad-spectrum antiviral agent against RNA viruses.

Techniques: Binding Assay

Journal: Antimicrobial Agents and Chemotherapy

Article Title: New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

doi: 10.1128/AAC.01814-20

Figure Lengend Snippet: Remdesivir characteristics and clinical guide ^a

Article Snippet: Remdesivir is a potentially broad-spectrum antiviral agent against RNA viruses.

Techniques: Inhibition, Activity Assay, Injection, In Vitro

Journal: Infection Prevention in Practice

Article Title: Bacterial burden and drug-resistant bacteria in healthcare workers' mobile phones: a study in Puerto Rican outpatient clinics

doi: 10.1016/j.infpip.2024.100432

Figure Lengend Snippet: Antimicrobial resistance profiles of Klebsiella pneumoniae and Acinetobacter spp. against broad-spectrum antibiotic isolated from healthcare workers' mobile phones at outpatient clinics

Article Snippet: Each isolate was tested against eight broad-spectrum standard antibiotic discs (Thermo Scientific Oxoid, USA): tobramycin (10 μg), cefotaxime (30 μg), ciprofloxacin (5 μg), ceftriaxone (30 μg), imipenem (10 μg), gentamicin (10 μg), ceftazidime (30 μg) and aztreonam (30 μg).

Techniques: Isolation

Journal: South African Journal of Botany

Article Title: Antibiotic-potentiation, antioxidant, cytotoxic, anti-inflammatory and anti-acetylcholinesterase potential of Antidesma madagascariense Lam. (Euphorbiaceae)

doi: 10.1016/j.sajb.2017.03.034

Figure Lengend Snippet: Fig. 1. Activity of AE in combination with conventional antibiotics against ATCC strains.

Article Snippet: All fractions of AE showed broad spectrum activity against ATCC and clinical strains (MIC 0.03–4.00 mg/mL).

Techniques: Activity Assay

Journal: Biochemistry and Biophysics Reports

Article Title: Antibacterial activity of peptide derivatives of dermaseptins against multidrug-resistant Klebsiella pneumoniae and Staphylococcus epidermis

doi: 10.1016/j.bbrep.2026.102449

Figure Lengend Snippet: The structure-function relationship of the dermaseptin S4 and B2 and their analogs interacting with S. epidermidis and K. pneumoniae membranes.

Article Snippet: Dermaseptin-PP from Phyllomedusa palliata , a rarely studied frog species, was found by Dong et al. [ ] to have broad-spectrum antibacterial activity against K. pneumoniae (ATCC 43816) at values of MIC = 1 μM and MBC = 2 μM, as well as a relatively low hemolytic impact (estimated HC50 = 38.77 μM).

Techniques: